<i>MC-1R</i> sequencing analysis.

MC-1R sequence analysis of an exemplary healthy donor (skin type 2/3, i), an exemplary melanoma patient (skin type 2/3, ii), three healthy donors with red hair and fair skin (skin type 1, 1–3) and 12 melanoma patients with skin type 1 (A–M). Alleles that have been shown to be associated with the red hair/fair skin phenotype are underlined; mutations which alter the ability to bind α-MSH and/or activate adenylyl cyclase are printed in bold and are underlined. Variations of the MC-1R gene that have been associated with an increased risk for melanoma development are shown in bold. het = heterozygous; hom = homozygous; wt = wildtype.