Analysis of human fluid proteomic studies related to aging and frailty

The data collection is organized into two complementary databases. The first database includes several distinct datasets from age- and frailty-related proteomic studies: Proteins identified in age-related studies with p-values prior to Benjamini-Hochberg correction Proteins identified in frailty-related studies with p-values prior to Benjamini-Hochberg correction Proteins identified in age-related studies with expression pattern after Benjamini-Hochberg correction Proteins identified in frailty-related studies with expression pattern after Benjamini-Hochberg correction Proteins commonly identified in age-related studies. Proteins commonly identified in frailty-related studies. Proteins shared between the two previous datasets, present in at least two age-related studies and two frailty-related studies. The second database includes results from biological pathways in two software: STRING and Reactome. These datasets were generated from the proteins extracted in the first database. The datasets include: STRING biological pathway results for proteins commonly identified in frailty-related studies. STRING biological pathway results for proteins commonly identified in age-related studies. STRING biological pathway results for proteins shared between the two previous groups (≥2 age-related and ≥2 frailty-related studies). Reactome pathway analysis results for proteins commonly identified in frailty-related studies. Reactome pathway analysis results for proteins commonly identified in age-related studies. Reactome pathway analysis results for proteins shared between the two previous groups. Summary of biological pathways results for proteins shared between the two previous groups. Meta-regression statistical results of STRING biological pathways across age- and frailty-related studies.本数据集分为两个互补数据库。 第一个数据库包含多项与年龄及衰弱相关的蛋白质组学研究的独立数据集，具体包括： - 年龄相关研究中鉴定得到的、带有本杰明尼-霍赫伯格（Benjamini-Hochberg）校正前p值的蛋白质 - 衰弱相关研究中鉴定得到的、带有本杰明尼-霍赫伯格校正前p值的蛋白质 - 年龄相关研究中鉴定得到的、带有本杰明尼-霍赫伯格校正后表达模式的蛋白质 - 衰弱相关研究中鉴定得到的、带有本杰明尼-霍赫伯格校正后表达模式的蛋白质 - 年龄相关研究中共同鉴定得到的蛋白质 - 衰弱相关研究中共同鉴定得到的蛋白质 - 上述两类数据集共享的蛋白质，即同时至少出现在2项年龄相关研究与2项衰弱相关研究中的蛋白质。 第二个数据库包含两款软件（STRING与Reactome）的生物通路分析结果，所有数据集均由第一个数据库中提取的蛋白质生成，具体包括： - 针对衰弱相关研究中共同鉴定得到的蛋白质的STRING生物通路分析结果 - 针对年龄相关研究中共同鉴定得到的蛋白质的STRING生物通路分析结果 - 针对上述两组蛋白质共享部分（同时满足≥2项年龄相关研究与≥2项衰弱相关研究）的STRING生物通路分析结果 - 针对衰弱相关研究中共同鉴定得到的蛋白质的Reactome通路分析结果 - 针对年龄相关研究中共同鉴定得到的蛋白质的Reactome通路分析结果 - 针对上述两组蛋白质共享部分的Reactome通路分析结果 - 针对上述两组蛋白质共享部分的生物通路分析结果汇总 - 跨年龄及衰弱相关研究的STRING生物通路的元回归统计结果。