Data from: Risk factors for ectopic pregnancy in Germany: a retrospective study of 100,197 patients

Aim: The goal of this study was to identify potential risk factors for ectopic pregnancy in women followed in German gynecological practices.
Methods: The present study included pregnant women diagnosed with ectopic pregnancy and pregnant women without ectopic pregnancy followed in 262 gynecological practices between January 2012 and December 2016. The effects of demographic and clinical variables on the risk of developing ectopic pregnancy were estimated using a multivariate logistic regression model.
Results: This study included 3,003 women with ectopic pregnancy and 97,194 women without ectopic pregnancy. The mean age was 31.4 years (SD=5.9 years) in ectopic pregnancy patients and 31.1 years (SD=5.6 years) in non-ectopic pregnancy patients. Women aged 36-40 (OR=1.12) and 41-45 years (OR=1.46) were at a higher risk of ectopic pregnancy than women aged 31-35 years. Prior ectopic pregnancy was strongly associated with a risk of recurring ectopic pregnancy (OR=8.17). Prior genital surgery (OR=2.67), endometriosis (OR=1.51), and eight other gynecological diseases were also positively associated with ectopic pregnancy (ORs ranging from 1.19 to 2.06). Finally, the risk of ectopic pregnancy was increased 1.80-fold in women previously diagnosed with psychiatric disorders.
Conclusions: Prior ectopic pregnancy and prior genital surgery were strongly associated with ectopic pregnancy in women followed in German gynecological practices. Psychiatric diseases had an additional impact on the risk of ectopic pregnancy.

研究目的：本研究旨在明确德国妇科诊疗机构随访女性人群中异位妊娠（ectopic pregnancy）的潜在危险因素。
研究方法：本研究纳入2012年1月至2016年12月期间，在262家妇科诊疗机构就诊的确诊异位妊娠孕妇与非异位妊娠孕妇。采用多因素logistic回归（logistic regression）模型，分析人口学与临床变量对异位妊娠发生风险的影响。
研究结果：本研究共纳入3003例异位妊娠孕妇与97194例非异位妊娠孕妇。异位妊娠组平均年龄为31.4岁（标准差SD=5.9岁），非异位妊娠组为31.1岁（SD=5.6岁）。相较于31~35岁女性，36~40岁（比值比（Odds Ratio）=1.12）与41~45岁（OR=1.46）女性的异位妊娠风险更高。既往异位妊娠史与复发性异位妊娠风险显著相关（OR=8.17）。既往生殖道手术史（OR=2.67）、子宫内膜异位症（endometriosis，OR=1.51）以及其余8种妇科疾病亦与异位妊娠呈正相关（OR值范围为1.19~2.06）。最后，既往确诊精神障碍的女性，其异位妊娠风险升高1.80倍。
研究结论：在德国妇科诊疗机构随访的女性人群中，既往异位妊娠史与生殖道手术史与异位妊娠风险显著相关；精神疾病亦会额外增加异位妊娠的发生风险。