Controlled therapeutic trials of biologics in primary Sjögren’s syndrome reported between 2002 and 2014.

TRIPPS: Trial of Remicade In Primary Sjogren's Syndrome; TEARS: Tolerance and EfficAcy of Rituximab in primary Sjögren syndrome; TRACTISS, Trial of Anti-B-Cell Therapy In primary Sjögren’s Syndrome; ETAP: Efficacy of Tocilizumab in Primary Sjögren's Syndrome; AECG, American-European Consensus Group criteria for primary Sjögren’s syndrome; ESR, erythrocyte sedimentation rate; Ig, immunoglobulin; pSS, primary Sjögren’s syndrome; VAS, visual analogue scale (0–100 mm); RF, rheumatoid factor; SGB: salivary gland biopsy; ESSDAI, European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease Activity Index; N, number of patients.Controlled therapeutic trials of biologics in primary Sjögren’s syndrome reported between 2002 and 2014.