Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE157983
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We studied conditional knockout mice in which the vast majority of dentate granule cells (DGCs) fail to develop – including nearly all DGCs in the dorsal hippocampus – secondary to eliminating Wntless (Wls) in a subset of cortical progenitors with Gfap-Cre. Bulk RNA-seq and single nuclei RNA-seq were preformed on hippocampi from adult control, Gfap-Cre;Wlsfl/+, and mutant, Gfap-cre;Wlsfl/- mice.
创建时间：
2020-10-27
