CD47 blockade augmentation of Trastuzumab antitumor efficacy dependent upon antibody-dependent-cellular-phagocytosis. CD47 blockade augmentation of Trastuzumab antitumor efficacy dependent upon antibody-dependent-cellular-phagocytosis

Analysis of HER2 breast tumor immune infiltrates in mice treated with murine Trastuzumab and CD47 checkpoint blockade therapy Overall design: Single Cell RNA Seq (scRNAseq) was performed on endogenous HER2-driven breast cancer in transgenic mice. The goal of this experiment is to compare effects of different antibody therapy combinations on tumor macrophages transcriptome