Effect of intravenous administration of maropitant on blood pressure in healthy awake and anesthetized dogs

Objective: To evaluate the effects of intravenous maropitant on arterial blood pressure in healthy dogs when awake and under general anesthesia. Design: Experimental crossover study Animals: Eight healthy adult Beagle dogs. Procedure: All dogs received maropitant 1 mg kg-1 intravenously during the following: awake with peripheral invasive blood pressure (BP) (Awake), anesthetized groups with premedication with either acepromazine 0.005 mg kg-1 and butorphanol 0.2 mg kg-1 (GaAB) or dexmedetomidine 0.005 mg kg-1 and butorphanol 0.2 mg kg -1 (GaDB) followed by general anesthesia with isoflurane. Heart rate (HR), systolic (SAP), diastolic (DAP) and mean blood pressures (MAP) were recorded before injection (baseline), during first 60 seconds of injection, during second 60 seconds of injection, at completion of injection and every 2 minutes post injection for 18 minutes in each group. The data were compared over time using Generalized Linear Model with mixed effects and then with simple effect comparison with Bonferroni adjustments (p <0.05) Edit log: the file "Research BP HR data individual dogs awake NIBP.csv" has been updated to correct the display of null values.

研究目的：评估静脉注射马罗匹坦（maropitant）对清醒状态及全身麻醉状态下健康犬的动脉血压（arterial blood pressure）的影响。
试验设计：交叉对照试验。
试验动物：8只健康成年比格犬（Beagle）。
试验步骤：所有受试犬在以下场景中均接受1 mg·kg⁻¹剂量的马罗匹坦静脉注射：① 清醒状态下采用外周有创血压（blood pressure, BP）监测（清醒组，Awake）；② 麻醉组：先分别给予两种术前给药方案——方案一为乙酰丙嗪（acepromazine）0.005 mg·kg⁻¹与布托啡诺（butorphanol）0.2 mg·kg⁻¹（GaAB组），方案二为右美托咪定（dexmedetomidine）0.005 mg·kg⁻¹与布托啡诺（butorphanol）0.2 mg·kg⁻¹（GaDB组），随后采用异氟烷（isoflurane）进行全身麻醉。
监测指标与记录时机：分别于注射前（基线）、注射初始60秒、注射后续60秒、注射结束时，以及注射后每2分钟连续记录18分钟的心率（heart rate, HR）、收缩压（systolic blood pressure, SAP）、舒张压（diastolic blood pressure, DAP）及平均动脉压（mean arterial blood pressure, MAP）。
数据分析：采用混合效应广义线性模型（Generalized Linear Model with mixed effects）对随时间变化的数据进行比较，随后采用Bonferroni校正（Bonferroni adjustments）的简单效应分析进行组间比较，检验水准设定为P<0.05。
编辑日志：已更新文件"Research BP HR data individual dogs awake NIBP.csv"，以修正空值的显示格式。