SCOP2

SCOP2 is a successor of Structural classification of proteins (SCOP). Similarly to SCOP, the main focus of SCOP2 is on proteins that are structurally characterized and deposited in the PDB. Proteins are organized according to their structural and evolutionary relationships, but, in contrast to SCOP, instead of a simple tree-like hierarchy these relationships form a complex network of nodes. Each node represents a relationship of a particular type and is exemplified by a region of protein structure and sequence. The previous version of SCOP is available at http://scop.mrc-lmb.cam.ac.uk/scop.SCOP2是蛋白质结构分类（Structural classification of proteins，SCOP）的继任版本。与SCOP相仿，SCOP2的核心研究重点为已完成结构表征并提交至蛋白质数据库（Protein Data Bank，PDB）的蛋白质。蛋白质依据其结构与进化关系进行分类组织，但与SCOP不同的是，此类关系并未形成简单的树状层级结构，而是构成了一张由节点组成的复杂网络。每个节点代表一种特定类型的关系，并以一段蛋白质结构与序列区域作为典型示例。此前版本的SCOP可通过http://scop.mrc-lmb.cam.ac.uk/scop访问。

搜集汇总

背景与挑战

背景概述

SCOP2是SCOP（蛋白质结构分类）的继任数据库，专注于对结构已知的蛋白质基于结构和进化关系进行网络化分类。它提供全面的蛋白质关系描述，截至2022年6月包含72,544个非冗余域，覆盖861,631个蛋白质结构，并支持按结构类和蛋白质类型浏览。