GDSC1

GDSC1 PharmacoSet (PSet) generated by ORCESTRA. Metadata can be found on ORCESTRA at: http://orcestra.ca/10.5281/zenodo.3905485 <strong>Disclaimer</strong> The GDSC1 data have been generated and shared by the Wellcome Trust Sanger Institute as part of the Genomics of Drug Sensitivity in Cancer (GDSC) Programme. The Haibe-Kains Lab has reprocessed and re-annotated the data to maximize overlap with other pharmacogenomic datasets. <strong>Data Usage Policy</strong> Users have a non-exclusive, non-transferable right to use data files for internal proprietary research and educational purposes, including target, biomarker and drug discovery. Excluded from this licence are use of the data (in whole or any significant part) for resale either alone or in combination with additional data/product offerings, or for provision of commercial services. Please note: The data files are experimental and academic in nature and are not licensed or certified by any regulatory body. Genome Research Limited provides access to data files on an “as is” basis and excludes all warranties of any kind (express or implied). If you are interested in incorporating results or software into a product, or have questions, please contact [e-mail]. Source: https://depmap.sanger.ac.uk/documentation/data-usage-policy/ Sanger's terms and conditions: http://www.cancerrxgene.org/legal <strong>Please cite the following when using these data</strong> Iorio F, Knijnenburg TA, Vis DJ, Bignell GR, Menden MP, Schubert M, Aben N, Gonçalves E, Barthorpe S, Lightfoot H, Cokelaer T, Greninger P, van Dyk E, Chang H, de Silva H, Heyn H, Deng X, Egan RK, Liu Q, Mironenko T, Mitropoulos X, Richardson L, Wang J, Zhang T, Moran S, Sayols S, Soleimani M, Tamborero D, Lopez-Bigas N, Ross-Macdonald P, Esteller M, Gray NS, Haber DA, Stratton MR, Benes CH, Wessels LFA, Saez-Rodriguez J, McDermott U, Garnett MJ. A Landscape of Pharmacogenomic Interactions in Cancer. Cell. 2016 Jul 28;166(3):740-754. doi: 10.1016/j.cell.2016.06.017. Epub 2016 Jul 7. PMID: 27397505; PMCID: PMC4967469. Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, Ramaswamy S, Futreal PA, Haber DA, Stratton MR, Benes C, McDermott U, Garnett MJ. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 2013 Jan;41(Database issue):D955-61. doi: 10.1093/nar/gks1111. Epub 2012 Nov 23. PMID: 23180760; PMCID: PMC3531057. Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ. Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening. Nat Commun. 2019 May 16;10(1):2198. doi: 10.1038/s41467-019-09940-1. PMID: 31097696; PMCID: PMC6522557.GDSC1 药物组学数据集（PharmacoSet, PSet）由ORCESTRA生成。其元数据可于ORCESTRA平台获取：http://orcestra.ca/10.5281/zenodo.3905485。 【免责声明】GDSC1数据集由威康桑格研究所（Wellcome Trust Sanger Institute）作为癌症药物敏感性基因组学（Genomics of Drug Sensitivity in Cancer, GDSC）计划的一部分生成并共享。海贝-凯因斯实验室（Haibe-Kains Lab）已对该数据进行重新处理与重新注释，以最大化其与其他药物基因组学数据集的重叠程度。 【数据使用政策】用户享有非排他性、不可转让的权利，可将数据文件用于内部专有研究与教育用途，包括靶点、生物标志物及药物发现研究。本许可禁止以下使用行为：将数据（全部或实质部分）单独或与其他数据/产品组合后转售，或将其用于提供商业服务。请注意：本数据文件为实验性与学术性资料，未经过任何监管机构的许可或认证。基因组研究有限公司（Genome Research Limited）按“现状”原则提供数据文件，并排除所有明示或默示的担保。若您有意将研究结果或软件整合至产品中，或有相关疑问，请联系[e-mail]。数据来源：https://depmap.sanger.ac.uk/documentation/data-usage-policy/ 桑格研究所条款与条件：http://www.cancerrxgene.org/legal 【引用要求】使用本数据集时，请引用以下文献： 1. Iorio F, Knijnenburg TA, Vis DJ, Bignell GR, Menden MP, Schubert M, Aben N, Gonçalves E, Barthorpe S, Lightfoot H, Cokelaer T, Greninger P, van Dyk E, Chang H, de Silva H, Heyn H, Deng X, Egan RK, Liu Q, Mironenko T, Mitropoulos X, Richardson L, Wang J, Zhang T, Moran S, Sayols S, Soleimani M, Tamborero D, Lopez-Bigas N, Ross-Macdonald P, Esteller M, Gray NS, Haber DA, Stratton MR, Benes CH, Wessels LFA, Saez-Rodriguez J, McDermott U, Garnett MJ. 癌症药物基因组学相互作用全景图谱. 《细胞》. 2016 Jul 28;166(3):740-754. doi: 10.1016/j.cell.2016.06.017. Epub 2016 Jul 7. PMID: 27397505; PMCID: PMC4967469. 2. Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, Ramaswamy S, Futreal PA, Haber DA, Stratton MR, Benes C, McDermott U, Garnett MJ. 癌症药物敏感性基因组学（GDSC）：癌细胞治疗性生物标志物发现资源. 《核酸研究》. 2013 Jan;41(Database issue):D955-61. doi: 10.1093/nar/gks1111. Epub 2012 Nov 23. PMID: 23180760; PMCID: PMC3531057. 3. Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ. 通过药理学与CRISPR-Cas9筛选评估基因融合与癌细胞适应性的功能关联. 《自然-通讯》. 2019 May 16;10(1):2198. doi: 10.1038/s41467-019-09940-1. PMID: 31097696; PMCID: PMC6522557.