MiRNA profiles of high grade serous papillary ovarian cancer tumors and normal fallopian tube epithelium

Fallopian tube epithelium is the tissue-of-origin of most high grade serous papillary ovarian carcinoma. This tumor has been exensively investigated and sequenced but expression profiling data of normal fallopian tube epithelial cells is still rare. This project compares the miRNA profiles of high grade serous papillary ovarian tumors (FFPE and fresh frozen) to that of normal unmatched epithelial cells from resected fallopian tubes. Total RNA was extracted using miRNeasy kit (QIAGEN) from FFPE ovarian cancer specimens, fresh frozen ovarian cancer specimens and fresh frozen fallopian tube epithelium.