NGS_dataset_on-target_'Prime editing as a promising therapeutic strategy for junctional epidermolysis bullosa'

Illumina MiSeq data of on-target analysis of prime edited JEB keratinocytes (+control) (DNA and cDNA) for publication 'Prime editing as a promising therapeutic strategy for junctional epidermolysis bullosa'; (C/CTR = control/mock; T = PE treated); Exon50, Exon52, and both exons in combined approach; + healthy control = HC; xenografts (DNA: PE+Ctr; cDNA: PE)本数据集为发表于论文《先导编辑（Prime Editing）作为交界性大疱性表皮松解症（Junctional Epidermolysis Bullosa, JEB）的极具前景的治疗策略》的相关数据，具体为经先导编辑处理的JEB角质形成细胞（附带对照组样本）的Illumina MiSeq靶向分析数据，涵盖脱氧核糖核酸（DNA）与互补脱氧核糖核酸（cDNA）两类样本；其中C/CTR代表对照/空白对照组（mock），T代表先导编辑（PE）处理组；分析覆盖外显子50、外显子52以及联合靶向策略下的双外显子区域；本数据集包含健康对照样本（记为HC）；同时包含异种移植模型样本，其中DNA样本涵盖PE处理组与对照组，cDNA样本仅包含PE处理组。