Crystal structure of NavAb V126T as a basis for the human Nav1.7 Inherited Erythromelalgia S241T mutation

Crystal structure of NavAb V126T as a basis for the human Nav1.7 Inherited Erythromelalgia S241T mutation Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein Authors: Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. Deposit date: 2022-06-29 Release date: 2023-04-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7. Proc.Natl.Acad.Sci.USA, 120, 2023NavAb V126T晶体结构：作为人类Nav1.7遗传性红斑性肢痛症S241T突变的研究基础 描述组分：1,2-二肉豆蔻酰-sn-甘油-3-磷酸胆碱、3-[(3-胆酰胺丙基)二甲基铵]-1-丙磺酸盐、离子转运蛋白 作者：Wisedchaisri G、Gamal El-Din T.M、Zheng N、Catterall W.A. 保藏日期：2022-06-29 发布日期：2023-04-12 最后更新日期：2023-10-25 实验方法：X射线衍射（3.1埃） 引用文献：电压门控钠通道NaV1.7的S4-S5连接区突变引发剧烈疼痛的结构基础，《美国国家科学院院刊》（Proc.Natl.Acad.Sci.USA），2023年，第120卷