首页/数据集/Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation.

Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation.

NIAID Data Ecosystem2026-05-02 收录

调节性T细胞功能

自身免疫抑制机制

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE262131 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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创建时间：

2024-12-11

调节性T细胞功能

转录调控机制

We investigated the role of Ikaros in regulatory Tcell identity and function during stimulation using RNA-seq, ATAC-seq, and H3K27ac/Foxp3/Ikzf1 ChIP-seq Overall design: We performed ATAC-seq, RNA-seq

NIAID Data Ecosystem80

Human Regulatory T Cell Suppressive Function Is Independent of Apoptosis Induction in Activated Effector T Cells

调节性T细胞功能

自身免疫疾病机制

BackgroundCD4+CD25+FOXP3+ Regulatory T cells (Treg) play a central role in the immune balance to prevent autoimmune disease. One outstanding question is how Tregs suppress effector immune responses in

NIAID Data Ecosystem40

Immunomodulation of Antigen Presenting Cells Promotes Natural Regulatory T Cells That Prevent Autoimmune Diabetes in NOD Mice

自身免疫疾病免疫治疗

调节性T细胞功能

Progression towards type 1 diabetes (T1D) in susceptible patients is linked to a progressive decline in the capacity of regulatory T cells (Treg) to maintain tolerance. As such, therapies aimed at red

Figshare2016-01-18 更新30

Transcription profile of WT and LKB1 (encoded by the gene Stk11)-deficient Treg cells. Mus musculus

调节性T细胞功能

免疫细胞转录组学

LKB1 deficiency in Treg cells impairs their survival, metabolism and suppressive function. To exclude the impact of excessive inflammation on LKB1-deficient Treg cells, we generated mixed bone marrow

NIAID Data Ecosystem50

Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells (RNA-Seq)

调节性T细胞功能

单细胞RNA测序

Ripk1 plays an important role as a regulator of programmed cell death processes such as apoptosis and necroptosis, and is involved in the initiation of pro-inflammatory NF-kB signaling. Immune toleran

NIAID Data Ecosystem30

Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation.

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