Preparation and In-vitro Evaluation of Metoprolol Tartrate Proniosomal Gel

The aim of this research is to prepare metoprolol tartrate niosomal gel as transdermal drug delivery system and also to evaluate procedure related variables like type of surfactant and release of drug from niosomes. Metoprolol tartrate niosomes are formulated by coacervation-phase separation method using different types of non-ionic surfactant (Span or Tween of different HLB value), lecithin and cholesterol. The prepared formulations are estimated for its entrapment efficiency, vesicle size (optical microscope and ABT-9000 NANO Laser particle size analyzer), the compatibility of the drug and additives used (Fourier Transform Infra Red -FT-IR spectroscopy) and morphological characters (Scanning Electron Microscopy-SEM). Fourier Transform Infra Red (FT-IR) studies, confirm that there is no interaction between drug and other formulation components of niosome. Higher entrapment efficiencies are obtained with Span 40 and span 60 (86.6%±8.07 and 78.09±15.44 respectively) and the release rate at 11 hr from span 40 niosomes is found to be 31.18%. In conclusion, the niosomal gel formulation could be a promising transdermal delivery system for metoprolol tartarate with prolonged drug release profiles. ‫مختبري‬ ‫وتقييم‬ ‫تحضير‬ ‫ل‬ ‫هالم‬ ‫البرونايوسوم‬ ‫ل‬ ‫تارتريت‬ ‫لميتوبرولول‬ 3 ,‫عباس‬ ‫كاظم‬ ‫حيدر‬ 3 ,‫فالح‬ ‫ايناس‬ 3 ,‫حسين‬ ‫هاشم‬ ‫احمد‬ 2 ,‫يوسف‬ ‫ال‬ ‫داخل‬ ‫محمد‬ 1 ‫شهيد‬ ‫قاسم‬ ‫ضرغام‬ -1 ‫الكوفة‬ ‫الصيدلة|جامعة‬ ‫كلية‬ |‫الصيدالنيات‬ ‫فرع‬ 2 -‫الكوفة‬ ‫الصيدلة|جامعة‬ ‫كلية‬ |‫السريرية‬ ‫الصيدلة‬ ‫فرع‬ 1 -‫الكيم‬ ‫فرع‬ ‫الكوفة‬ ‫الصيدلة|جامعة‬ ‫كلية‬ |‫الصيدالنية‬ ‫ياء‬

本研究旨在制备美托洛尔酒石酸盐的脂质体凝胶作为经皮给药系统，并评估与制备过程相关的变量，例如表面活性剂类型和药物从脂质体中的释放。美托洛尔酒石酸盐脂质体的制备采用共凝聚相分离法，使用不同类型的非离子表面活性剂（不同HLB值的Span或Tween）、卵磷脂和胆固醇。制备的制剂对其包封效率、囊泡大小（光学显微镜和ABT-9000 NANO激光粒度分析仪）、药物与所用添加剂的相容性（傅里叶变换红外光谱 - FT-IR）以及形态学特征（扫描电子显微镜 - SEM）进行了评估。傅里叶变换红外光谱（FT-IR）研究表明，药物与脂质体的其他组分之间不存在相互作用。采用Span 40和Span 60（分别达到86.6%±8.07和78.09±15.44的包封效率）可获得更高的包封效率，且从Span 40脂质体中在11小时时的释放率为31.18%。总之，脂质体凝胶制剂可能成为美托洛尔酒石酸盐长效释放的经皮给药系统。