HVN1917 Rua Metadata Record - Tuhauora ka tahi: Effects of kawakawa containing beverage on the energy metabolism and physiology in healthy human volunteers

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.Description: Kawakawa (Piper excelsum) is endemic to Aotearoa, New Zealand, and, as a taonga, is of great cultural importance to Maori. Kawakawa is used extensively in rongoa Maori (traditional Maori healing). The pharmacology of kawakawa is complex, with studies reporting kawakawa to contain several biologically active compounds that influence inflammation and related pathways. For example, myristicin inhibits the production of several pro-inflammatory cytokines, such as NO, IL-6 and IL-10, in mouse macrophages and THP-1 monocytes. Elemicin, another aromatic compound in kawakawa, is known to play a role in inhibiting IL-6. We hypothesize that the consumption of kawakawa would impact the inflammatory pathways by enhancing anti-inflammatory effects. However, several confounding variables, such as individualized differences in kawakawa tea preparation and doses and variability in the bioavailability of the active kawakawa constituents, could also alter the anti-inflammatory effects. Therefore, controlled human kawakawa trials are necessary to evaluate the effects of different doses of kawakawa consumption on inflammatory markers. To test our hypothesis, this study aims to quantify the effects of different kawakawa doses on inflammatory markers in healthy human volunteers.

本元数据记录及其附属文件阐明了本研究所采集的数据类型，并制定了该数据当前及未来的治理规范。数据集说明：Kawakawa (Piper excelsum) 为新西兰（Aotearoa）特有物种，作为毛利文化宝物（taonga），对毛利族群具有极高的文化重要性。该物种广泛应用于毛利传统医疗（Rongoa Māori），其药理学特性较为复杂，已有研究表明其含有多种可调控炎症及相关通路的生物活性成分。例如，肉豆蔻醚（myristicin）可在小鼠巨噬细胞与THP-1单核细胞中抑制一氧化氮（NO）、白细胞介素-6（IL-6）及白细胞介素-10（IL-10）等多种促炎细胞因子的产生。另一种存在于Kawakawa中的芳香类化合物榄香素（elemicin），已知可抑制IL-6的表达。本研究团队提出假设：摄入Kawakawa可通过增强抗炎效应影响炎症通路。然而，诸多混杂变量可能改变其抗炎效果，例如Kawakawa茶制备方式与剂量的个体差异，以及活性成分生物利用度的波动。因此，开展人体Kawakawa对照试验，对评估不同剂量Kawakawa摄入对炎症标志物的影响至关重要。为验证上述假设，本研究旨在量化不同剂量Kawakawa摄入对健康人体志愿者体内炎症标志物的影响。