Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol

Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol Descriptor: 7-(((2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one, CALCIUM ION, IAG-nucleoside hydrolase, ... Authors: Versees, W, Goeminne, A, Berg, M, Vandemeulebroucke, A, Haemers, A, Augustyns, K, Steyaert, J. Deposit date: 2008-09-30 Release date: 2009-03-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors. Biochim.Biophys.Acta, 1794, 2009

伊氏锥虫（Trypanosoma vivax）核苷水解酶与抑制剂(2R,3R,4S)-1-[(4-羟基-5H-吡咯并[3,2-d]嘧啶-7-基)甲基]-2-(羟甲基)吡咯烷-3,4-二醇结合的晶体结构。配体描述：7-(((2R,3R,4S)-3,4-二羟基-2-(羟甲基)吡咯烷-1-基)甲基)-3H-吡咯并[3,2-d]嘧啶-4(5H)-酮、钙离子、IAG-核苷水解酶……。作者：Versees, W、Goeminne, A、Berg, M、Vandemeulebroucke, A、Haemers, A、Augustyns, K、Steyaert, J。沉积日期：2008-09-30，发布日期：2009-03-24，最后修改日期：2023-09-06。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.3埃（Å）。引用：伊氏锥虫核苷水解酶与新型强效特异性抑制剂结合的晶体结构。《生物化学与生物物理学学报（Biochim.Biophys.Acta）》，179卷，2009年。