GSE45255 Expression Data

Expression Profiles of Breast Tumors from Singapore and Europe. To facilitate a better understanding of the molecular heterogeneity of breast cancer and to uncover gene-survival associations that segregate with distinct molecular subtypes, we recently compiled a meta-analytical database of over 2,000 human breast tumor expression profiles variously annotated for clinical and pathological variables and derived from various institutions worldwide. This database was utilized for the breast tumor study cited below: Nagalla, et. al., Genome Biology, 2013. While the majority of the tumor expression profiles included in this database derived from publicly accessible microarray repositories, a number of the samples had not been previously published. Here, we describe the origin of these samples and provide their associated clinical and pathological annotations with the hope that other investigators will be able to utilize these data in their own research.新加坡及欧洲乳腺肿瘤表达谱数据集 为深入解析乳腺癌的分子异质性，并挖掘可区分不同分子亚型的基因-生存关联，我们近期构建了一个包含2000余例人类乳腺肿瘤表达谱的荟萃分析数据库。该数据库涵盖全球多家研究机构来源的样本，所有样本均附带临床与病理变量注释。 该数据库已被应用于下述乳腺肿瘤研究：Nagalla等发表于《Genome Biology》2013年的研究。 尽管该数据库中的多数肿瘤表达谱数据来自公开可获取的微阵列数据库，但仍有部分样本此前从未公开发表。本文将详细说明这批未发表样本的来源，并提供其配套的临床与病理注释信息，以期其他研究者可将这些数据用于自身的科研工作。