Direct Catalytic Asymmetric Aldol Addition of an α‑CF<sub>3</sub> Amide to Arylglyoxal Hydrates
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Direct asymmetric aldol addition of an α-CF3 amide to arylglyoxal hydrates was promoted by a chiral catalyst comprising a soft Lewis acidic Cu(I), a chiral bisphosphine ligand, and DBU. The 7-azaindoline moiety of the amide facilitates its enolization and stabilizes the thus-generated Cu enolate, furnishing enantioenriched aldol adducts.
创建时间：
2017-07-19
