Artesunate dosing schedule for mice infected with P. v. vinckei.

There were ten experimental groups. All groups except the untreated received a total dose of 256 mg/kg of AS.* = Time point chosen because previous in vitro studies with P. falciparum showed that following treatment with dihydroartemisinin (DHA), dormant ring-stage parasites start to resume growth (i.e. normal parasite stages observed) on days 4–5 post-treatment (PT). We wanted to assess how treatment at this time-point would affect parasite recrudescence in vivo. N/A = not applicable; PT = post-treatment; PI = post-infection.