Genetic and sex-specific regulation of mitochondrial function in gonadal and inguinal adipose tissue

Sex differences in adipose tissue impact metabolic health, but the underlying molecular mechanisms remain unclear. We previously identified a female-specific chr17 trans-eQTL hotspot regulating mitochondrial gene expression in gonadal white adipose tissue (gWAT). Here, we tested whether iWAT contributes comparably to sex differences in mitochondrial function and futile cycling. RNA-Seq profiling of subcutaneous adipose tissue from 82 strains of inbred mice (67 for females, 74 for males)