Cobalt-Catalyzed Enantioselective Directed C–H Alkylation of Indole with Styrenes
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A cobalt–chiral phosphoramidite catalyst promotes enantioselective imine-directed C2-alkylation of Boc-protected indoles with styrenes. The reaction affords 1,1-diarylethane products in moderate to good yields with good enantioselectivities under mild conditions. A deuterium-labeling experiment suggests that the enantioselectivity is controlled by both the styrene insertion and the C–C reductive elimination steps.
创建时间：
2015-01-02
