True DMRs in 3 versus 3 sample comparison benchmark

True DMRs in 3 versus 3 sample comparison benchmark This file contains the true differentially methylated regions (DMRs) for the 3 vs 3 comparison saved as a `.bed` (standard bed format). Each row corresponds to one of the 3000 simulated DMRs, and the first three columns denote their position: chromosome, start position, end position. This benchmark data was created to mimic the properties of real WGBS data in order to evaluate the method dmrseq (described in the preprint at https://doi.org/10.1101/183210). This was done by splitting a set of biological replicates (controls) into two artificial groups and adding methylation differences to randomly selected regions. Differences are added between the first half of samples and the second half of samples. More methodological details and a script to reproduce the generation of this data file is available at the companion repository: https://github.com/kdkorthauer/dmrseqPaper.

3 vs 3样本对比基准中的真实差异甲基化区域（differentially methylated regions, DMRs）
本文件存储了该3 vs 3样本对比场景下的真实差异甲基化区域，格式为标准`.bed`文件格式。文件中每一行对应3000个模拟差异甲基化区域中的一个，前三列分别标注其基因组位置：染色体、起始位点与终止位点。
本基准数据集旨在模拟真实全基因组亚硫酸氢盐测序（Whole Genome Bisulfite Sequencing, WGBS）数据的特征，用于评估dmrseq分析方法（该方法的预印本详见https://doi.org/10.1101/183210）。
数据集构建方式为：将一组生物学重复样本（对照组）划分为两个人工分组，并向随机选取的区域引入甲基化差异，差异设置于前半部分样本与后半部分样本之间。
更多方法学细节以及可复现该数据文件生成的脚本，可参阅配套代码仓库：https://github.com/kdkorthauer/dmrseqPaper。