Human tRF & tiRNA sequencing in serum of sarcoidosis

Transfer-RNA-Derived Small RNA (tsRNA) is a novel class of short non-coding RNA including stress-induced tRNA fragments (tiRNA) and tRNA-derived fragments (tRF). Using RNA sequencing, we evaluated the tsRNA expression profiles in the serum of sarcoidosis (n = 3) compared with healthy control group (n = 3). Bioinformatics analyses indicated that tsRNAs were the important regulators and potential new biomarkers of sarcoidosis. Overall design: tiRNA and tRF profiles in serum of sarcoidosis compared with healthy control group, in triplicate, using Illumina NextSeq 500 system.