High reproducibility of adenosine stress cardiac magnetic resonance myocardial perfusion imaging in patients with nonischemic dilated cardiomyopathy

Objective: To evaluate the reproducibility of first-pass contrast-enhanced cardiac MR (CMR) myocardial perfusion imaging in patients with non-ischaemic dilated cardiomyopathy (NIDCM). Design: Prospective observational study. Setting: Single centre, tertiary care hospital. Participants: 6 outpatient participants with NIDCM. Outcome: Reproducibility of semiquantitative myocardial perfusion analysis by CMR. Method: 6 patients with NIDCM were studied twice using first-pass of contrast transit through the left ventricular (LV) myocardium with a saturation-recovery gradient echo sequence at rest and during adenosine-induced hyperaemia. The anterior wall was divided into endocardial (Endo) and epicardial (Epi) segments. The Myocardial Perfusion Index (MPI) was calculated as the myocardial signal augmentation rate normalised to the LV cavity rate. The Myocardial Perfusion Reserve Index (MPRI) was calculated as hyperaemic/resting MPI. Results: Between study 1 and 2, median MPI was similar for re...

研究目的：评估非缺血性扩张型心肌病（NIDCM）患者首过对比增强心脏磁共振（CMR）心肌灌注成像的可重复性。
研究设计：前瞻性观察性研究。
研究场景：单中心三级医院。
研究对象：6名非缺血性扩张型心肌病（NIDCM）门诊受试者。
核心结局指标：心脏磁共振（CMR）半定量心肌灌注分析的可重复性。
研究方法：对6名非缺血性扩张型心肌病（NIDCM）患者开展两次成像检查：分别于静息状态及腺苷诱导的充血状态下，采用饱和恢复梯度回波序列采集对比剂首过通过左心室（LV）心肌的图像。将左心室前壁划分为心内膜下（Endo）与心外膜下（Epi）两个节段。以左心室腔信号增强率作为标准化参照，计算心肌灌注指数（MPI），即心肌信号增强率经左心室腔信号增强率标准化后的值。心肌灌注储备指数（MPRI）以充血状态下与静息状态下的心肌灌注指数的比值计算得到。
研究结果：两次研究间，首次与第二次测量的中位心肌灌注指数（MPI）在...