Systemic proteome adaptions to 7-day complete caloric restriction in humans

We conducted a proteomic experiment among 12 healthy volunteers (5 women, 7 men) participating in a 7-day water-only fast. About 3000 proteins were measured using the Olink Explore 3072 Technology from plasma samples drawn daily under the intervention, as well as two days before and three days thereafter. The data provided here have been prepared according to what has been reported in this publication (link to be added), which you need to cite when publishing with this data. Data usage agreement & data access By downloading any of the data provided, you agree to the following conditions. PLEASE READ THESE LICENCE TERMS CAREFULLY. Disclaimer statement These data are provided on an “as-is” basis, without warranty of any type, expressed or implied, including but not limited to any warranty as to their performance, merchantability, or fitness for any particular purpose. Investigators will use these results for scientific research and educational use only, use for commercial businesses is not permitted. Investigators will not include these results in meta-analyses of any kind for single or more entities (protein targets/metabolites) without explicit written consent and/ or a collaborative agreement with the respective data owners (corresponding author(s)). Reposting or distribution of omicscience results files is prohibited. Investigators certify that they are in compliance with all applicable local, state, and federal laws or regulations and institutional policies regarding human subjects and genetics research. Investigators will never attempt to identify any participants. Investigators will cite the appropriate omicscience publications, this resource (www.omicscience.org) and respective acknowledgements in any communications or publications arising directly or indirectly from these data. All data is made available under a CC-BY-NC-ND 4.0 International license. Data provided We provide two files. 'Fasting.proteomics.Olink.Explore.label.20240109.txt' contains basic informations about assayed protein targets, including protein encoding genes. The column 'OlinkID' refers to the entries in the data set and 'Assay' contains the name of the protein. Please note that some proteins have been measured multiple times. 'Fasting.proteomics.Olink.Explore.20240109.txt' contains NPX values (log2 scale) for a total of 2941 Olink Assays targeting 2923 unique proteins. Missing values are coded as 'NA'. There are two columns providing unique identifiers for each sample. 'Participant' is a randomly generated ID indicating from which participant the sample has been drawn, and 't.point' indicates the timepoint (days) at which the sample has been drawn. The timepoints -2 and 0 mark measurements before the fasting intervention, 1-7 measurements during the intervention (all morning samples), and 10 marks 3 days after participants resumed eating. Please see the related publication or the study design below for more details.我们招募了12名健康志愿者（5名女性，7名男性）开展为期7天的纯水禁食蛋白质组学实验。研究人员每日采集干预期间的血浆样本，并在干预前2天及干预结束后3天采集样本，采用Olink Explore 3072技术对样本中的蛋白质进行检测，共定量到约3000种蛋白质。本数据集已按照已发表的研究（待补充链接）进行整理，若使用该数据进行发表，需引用该文献。 数据使用协议与数据获取 下载本数据集任意内容即代表您同意以下条款。 请仔细阅读以下许可协议条款。 免责声明 本数据集按“现状”提供，不附带任何明示或暗示的担保，包括但不限于关于其性能、适销性或特定用途适用性的担保。 仅允许科研人员将本结果用于科学研究与教育用途，禁止用于商业用途。 未经数据所有者（通讯作者）明确书面同意或签署合作协议，不得将本结果用于任何针对单个或多个实体（蛋白质靶点/代谢物）的荟萃分析。 禁止转发或分发组学科学（omicscience）相关结果文件。 研究人员需确保其遵守所有适用的地方、州及联邦法律法规，以及涉及人类受试者与遗传学研究的机构政策。 研究人员不得尝试识别任何受试者身份。 在因本数据集直接或间接产生的所有交流或发表成果中，需引用相关组学科学文献、本资源（www.omicscience.org）及相应致谢内容。 本数据集采用CC-BY-NC-ND 4.0国际许可协议进行授权。 数据集内容 本次提供两个数据文件： 1. **Fasting.proteomics.Olink.Explore.label.20240109.txt**：包含待测蛋白质靶点的基础信息，包括其编码基因。其中“OlinkID”列对应数据集中的条目，“Assay”列为蛋白质名称。请注意，部分蛋白质被多次定量。 2. **Fasting.proteomics.Olink.Explore.20240109.txt**：包含共计2941个Olink检测试剂盒的NPX值（以log2为底数的对数尺度），对应2923种独特蛋白质。缺失值以“NA”编码。该文件包含两列唯一样本标识符：“Participant”为随机生成的受试者ID，用于标识样本来源受试者；“t.point”为样本采集的时间点（天数）。时间点-2和0代表禁食干预前的两次采样，1至7代表干预期间的每日采样（均为晨间样本），10代表受试者恢复进食后的第3天采样。更多细节请参阅相关发表文献或下文的研究设计。