DNA methylation in developing country

we reviewed the effect of poor life conditions of pregnant mother living in developing countries on DNA methylation of their neonates and there making susceptible the newborn himself and also his/her upcoming generation susceptible to chronic disease. we searched PubMed, google scholar, Web of Science, Crossref for the original research conducted in developing countries to assess the effect of nutrient deficient diet, stress and pollution on neonatal DNA methylation. however due to limited research conducted in developing countries we were not able to do meta analyses but we reviewed the results of available knowledge dietary habits in most of developing countries and shortage of food causes the deficiency of essential nutrient and therefore, causes aberrant DNA methylation or the methylation of the most important genes, but more research is needed. To study the effect of pollutants, and stress there were not sufficient studies conducted in developing countries so we included the studies conducted in upper middle income countries or data of high income countries, then compared with the possible effect in developing countries, definitely the results may
be sever in developing countries.

本研究系统探讨了发展中国家孕妇的不良生活状况对其子代新生儿DNA甲基化（DNA methylation）的影响，以及该表观遗传修饰变化如何使新生儿自身及其后代罹患慢性疾病的风险升高。本研究检索了PubMed、Google Scholar、Web of Science、Crossref数据库，筛选开展于发展中国家的原创性研究，以评估营养缺乏饮食、应激与污染对新生儿DNA甲基化的作用。但由于发展中国家相关研究数量有限，本研究未能开展荟萃分析（meta-analysis）。不过本研究整合了现有研究结论：多数发展中国家居民的饮食习惯及食物短缺问题会引发必需营养素缺乏，进而导致异常DNA甲基化或关键基因甲基化，但该领域仍需开展更多相关研究。针对污染物与应激的影响，发展中国家的现有研究数量不足，因此本研究纳入了中高收入国家的相关研究或高收入国家的数据集，并与发展中国家的潜在影响进行对比分析，可以确定，发展中国家的相关不良效应可能更为严重。