Effect of imatinib on FIP1L1-PDGFRA-expressing EOL1 cells
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE15237
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The Eol1 cell line has been derived from a patient with chronic eosiniphilic leukemia. Eol1 cells express the FIP1L1-PDGFRalpha oncogene. Inhibition of FIP1L1-PDGFRalpha with imatinib mesylate (Glivec) blocks proliferation and survival of the cells. We performed microarray expression analysis to identify genes specifically regulated by FIP1L1-PDGFRalpha using imatinib-treated cells as baseline. The list of regulated genes was consistent with the activation of STAT trancription factors by FIP1L1-PDGFRA. Keywords: 4 hours treatment with Glivec Eol1 cells were cultured in presence or absence of Glivec for 4 hours before RNA extraction and hybridization on Affymetrix microarray.
创建时间：
2019-03-25
