TCGA-CESC

The Cancer Genome Atlas Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA-CESC) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from The Cancer Genome Atlas (TCGA). Clinical, genetic, and pathological data resides in the Genomic Data Commons (GDC) Data Portal while the radiological data is stored on The Cancer Imaging Archive (TCIA). Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial.

癌症基因组图谱宫颈鳞状细胞癌与宫颈内腺癌（TCGA-CESC）数据集集合，是一项更大规模研究计划的组成部分。该计划旨在构建一个研究共同体，通过为来自癌症基因组图谱（TCGA）的受试者匹配临床影像，实现癌症表型与基因型的关联研究。其中，临床、遗传与病理数据存储于基因组数据共享（Genomic Data Commons, GDC）数据门户，而放射学影像数据则储存在癌症影像档案（The Cancer Imaging Archive, TCIA）中。匹配的TCGA患者标识符可支持研究人员在TCGA与TCIA数据库中，探索组织基因型、放射学表型与患者预后之间的相关性。TCGA的组织样本采集自全球各地的众多站点，以达成每种癌症类型约500份标本的招募目标。正因如此，该影像数据集在扫描模态、设备厂商与采集协议方面均呈现出极强的异质性。在绝大多数场景中，影像数据均作为常规诊疗流程的一部分完成采集，而非受控研究或临床试验的组成部分。

搜集汇总

背景与挑战

背景概述

TCGA-CESC数据集是TCGA项目的一部分，专注于宫颈鳞状细胞癌和宫颈腺癌，旨在通过整合临床图像与TCGA受试者数据，连接癌症表型与基因型以促进研究。数据包括临床、遗传、病理和放射学信息，分别存储在GDC和TCIA，允许研究人员探索组织基因型、放射学表型与患者结果之间的相关性。该数据集具有高度异质性，因为组织收集自全球多个站点，图像数据来自常规护理，涉及多种扫描仪和协议。