Apoe^em1Ejt

The mutant rat strain was produced by injecting TALEN system targeting the exon 4 of rat Apoe into Sprague Dawley (Hsd:SD) embryos. This mutant rat has a 16-bp deletion in the gene third coding exon) located on chromosome 1; frameshift mutation resulted (p.Glu178fs)<br>ASSOCIATED WITH abnormal aorta morphology; increased systemic arterial blood pressure; ASSOCIATED WITH familial hypercholesterolemia

通过向Sprague Dawley（Hsd:SD）胚胎中注射靶向鼠Apoe基因第4外显子的TALEN系统，成功培育出突变型大鼠。该突变型大鼠在第1号染色体上的基因第三编码外显子存在16个碱基的缺失；由此引起的移码突变（p.Glu178fs）与主动脉形态异常相关；与系统性动脉血压升高相关；且与家族性高胆固醇血症相关。