Immune Response of Transplanted Kidney Tissues Assembled from Organoid Building Blocks

The transcriptional profile of kidney organoid-based tissues resembled the gene signature observed in human kidney transplant rejection when transplanted into mice reconstituted with an allogeneic immune system. Gene expression profiles of kidney tissues assembled from organoid building blocks harvested from NSG mice with no immune system, or reconstituted with allogeneic human immune cells treated or not with Rapamycin