Single-cell RNAseq of mesenteric adipose tissue from Crohn's disease patients and healthy controls

As a hallmark of Crohn's disease (CD)，creeping fat (CF) is intimately related to intestinal fibrosis and postoperative recurrence. It is defined as expansion of mesenteric adipose tissue envelops the diseased intestinal segment. Compared with the healthy controls, CF has enriched functions related to adipogenesis and immune response. Single-cell RNA-seq analysis of stromal vascular fraction (SVF) isolated from the mesenteric fat tissue (MAT) of patients undergoing bowel resection. Creeping fat from Crohn's disease patients (n=6), CD-MAT from the same patients (n=3) and healthy MAT from ileal controls (n=2).