Structure of the Na+ channel variants used in this study.
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Previously we used the hH1 clone [30] as the reference hNav1.5 sequence to investigate the effect of the T1620K mutation on channel kinetics [29]. The corresponding protein sequence includes amino acids encoded by exon 6b as well as H558, Q1027, and Q1077. T1620K carriers and unaffected family members presented with R558 and H558, respectively. As shown previously, the polymorphism at this position did not differentially affect channel kinetics [29].
创建时间：
2015-12-02
