Derivation and Evaluation of Putative Adverse Outcome Pathways for Effects of Cycylooxygenase inhibitors on Reproductive Processes in Female Fish

Fathead minnows (Pimephales promelas) were exposed to 100 ug/L indomethacin, 200 ug/L ibuprofen, or 20 ug/L celecoxib for 96 h. Effects on cycloxygenase enzyme...将黑头呆鱼（Pimephales promelas）暴露于100 μg/L吲哚美辛（indomethacin）、200 μg/L布洛芬（ibuprofen）或20 μg/L塞来昔布（celecoxib）中处理96小时，以探究其对环氧合酶（cycloxygenase）的作用效应……