Volumes (in mm3) of 22 brain structures in mouse models of Duchenne muscular dystrophy.

The volumes of 22 segmented brain structures in mdx, BL10, mdx-XistΔhs and BL10-XistΔhs mice are presented in mm3. Body mass was measured just before sacrificing the mice, except for two mdx-XistΔhs mice of which body mass was not obtained. The volumes of these 22 structures were normalized to whole brain volume and compared using Welch’s T-tests within each genetic background (mdx vs BL10 and mdx-XistΔhs vs BL10-XistΔhs) and corrected for multiple comparisons using the false discovery rate. The corresponding P-values are presented and structures which are significantly different in volume are written in bold. The hippocampus, globus pallidus, caudate putamen and hypothalamus were different between mdx and BL10 mice. Thirteen structures were different between mdx-XistΔhs and BL10-XistΔhs mice, consisting of a mixture of both grey and white matter structures.