Agonist classification by the simplified structural view of allostery.

Column 1 gives the number of allosteric and functional sites as specified in the structural view of allostery. For example, A1/F2 stands for the allosteric system containing one allosteric site and two functional sites. The second and third columns give the classification of ligand bound at the two allosteric sites. Blanks in the table mean that the item does not apply to the classification. The classification is based on the next six columns which correspond to the six allosteric efficacies defined in Figure 5B, Figure S3, Figure 5C, and Figure 6C, respectively, for the A1/F1, A1/F2, A2/F1, and A2/F2 systems.