Dataset for article "Molecular solutions to RNA self-cleavage are numerous yet evolution favors a few"

The Data.zip file consists of the following directories. Sparse-tiling: Sequences of all 141,993 sparsely tiled circular RNAs and the cleavage scores of 720,000 tiles derived from them. See _Notes.txt for a detailed description of each file. Dense-tiling: Sequences of all 12,370 densely tiled circular RNAs and the cleavage scores of 717,579 tiles derived from them. See _Notes.txt for a detailed description of each file. DMS: Cleavage scores of the 105 wild-type ribozymes and their 84,396 mutants. See _Notes.txt for a detailed description of each file. Clip: Sequences and cleavage scores of all putative clip ribozymes identified and assayed. See _Notes.txt for a detailed description of each file. Miscellaneous: Clip covariance models and the expression vector sequence. The Scripts.zip file contains the scripts for analyzing the cleavage score measurements. They are categorized by the dataset analyzed (Dense-tiling, DMS, and Clip). Those in Base-scripts are required for all three types of analyses. See the comments inside each script for a detailed description. Raw sequencing reads and the scripts for processing them into cleavage scores are not provided here because of size restrictions. They are available upon request.本Data.zip压缩包包含如下目录： 稀疏平铺（Sparse-tiling）：包含全部141993条稀疏平铺环状RNA的序列，以及由此生成的720000个平铺片段的切割得分。各文件的详细说明详见_Notes.txt。 密集平铺（Dense-tiling）：包含全部12370条密集平铺环状RNA的序列，以及由此生成的717579个平铺片段的切割得分。各文件的详细说明详见_Notes.txt。 DMS：包含105种野生型核酶及其84396个突变体的切割得分。各文件的详细说明详见_Notes.txt。 Clip：包含所有经鉴定与实验检测的推定clip核酶的序列与切割得分。各文件的详细说明详见_Notes.txt。 杂项（Miscellaneous）：包含clip协方差模型与表达载体序列。 本Scripts.zip压缩包包含用于切割得分检测数据解析的脚本，按所分析的数据集类别（密集平铺、DMS与Clip）进行分类。其中Base-scripts目录下的脚本为三类分析均必需的基础脚本，详细说明详见各脚本内部的注释。 由于文件大小限制，原始测序读数及用于将其处理为切割得分的脚本未在此提供。如有需求，可应要求获取。