RNA-seq analysis revealed genes associated with Artesunate treated experimental cerebral malaria mice brain. Mus musculus

Cerebral malaria has a high mortality rate and some patients have neurological sequelae even after treatment with antimalarial drugs.This study aimed to investigate the transcriptome-wide response of experimental cerebral malaria (ECM) and artesunate treated mice brain on 6 days post-infection.C57BL/6 mice were infected with lasmodium berghei ANKA to construct a murine ECM in MB and AB group. AB group treated with artesunate, while CB group treated with 1xphosphate buffer saline(PBS) solution for 4 days. Mice brain was tested by RNA-seq. This study revealed a transcriptome-wide profile in ECM and artesunate treated mice brain, and help to explore the underlying mechanism, as well as the further development of therapeutic strategies for clinical cerebral malaria.