HIV-1 Integrase catalytic core domain complexed with allosteric inhibitor STP03-0404

HIV-1 Integrase catalytic core domain complexed with allosteric inhibitor STP03-0404 Descriptor: (2S)-tert-butoxy{4-(4-chlorophenyl)-2,3,6-trimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, Integrase Authors: Lindenberger, J.J, Kvaratskhelia, M. Deposit date: 2020-10-09 Release date: 2021-09-22 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.19 Å) Cite: A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site. Plos Pathog., 17, 2021

HIV-1整合酶催化核心结构域与变构抑制剂（allosteric inhibitor）STP03-0404的复合物。描述符：(2S)-叔丁氧基{4-(4-氯苯基)-2,3,6-三甲基-1-[(1-甲基-1H-吡唑-4-基)甲基]-1H-吡咯并[2,3-b]吡啶-5-基}乙酸，整合酶（Integrase）。作者：Lindenberger, J.J.、Kvaratskhelia, M.。提交日期：2020-10-09；发布日期：2021-09-22；最后修改日期：2024-11-06。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.19埃。引用文献：靶向宿主LEDGF/p75-整合酶相互作用位点的强效且安全的吡咯并吡啶类变构HIV-1整合酶抑制剂。《公共科学图书馆·病原体》（Plos Pathog.），第17卷，2021年。