Functionalized Cyclobutenes via Multicomponent Thermal [2 + 2] Cycloaddition Reactions
收藏NIAID Data Ecosystem2026-03-06 收录
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资源简介：
Enamine [2 + 2] cycloadditions can be achieved in useful yields simply by stirring a mixture of an aldehyde, diethylamine, a dialkyl fumarate, and potassium carbonate in acetonitrile at 25 °C, conditions that are compatible with the presence of a potential leaving group on the β-position of the intermediate enamine. Methylation and elimination of the product cyclobutanes completes a mild nonphotochemical route to functionalized cyclobutenes.
创建时间：
2016-05-05
