X-ray structure of CYP51 from the human pathogen Trypanosoma brucei in complex with fluconazole

X-ray structure of CYP51 from the human pathogen Trypanosoma brucei in complex with fluconazole Descriptor: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, LANOSTEROL 14-ALPHA-DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE Authors: Chen, C.-K, Leung, S.S.F, Guilbert, C, Jacobson, M, McKerrow, J.H, Podust, L.M. Deposit date: 2009-10-12 Release date: 2009-11-10 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole Plos Negl Trop Dis, 4, 2010

人类病原体布鲁氏锥虫（Trypanosoma brucei）细胞色素P450 51（CYP51）与氟康唑（fluconazole）形成复合物的X射线晶体结构。相关描述符：2-(2,4-二氟苯基)-1,3-二(1H-1,2,4-三唑-1-基)丙-2-醇、羊毛甾醇14α-去甲基化酶（LANOSTEROL 14-ALPHA-DEMETHYLASE）、含铁原卟啉IX（PROTOPORPHYRIN IX CONTAINING FE）。作者：Chen C.-K、Leung S.S.F、Guilbert C、Jacobson M、McKerrow J.H、Podust L.M.。存档日期：2009-10-12；发布日期：2009-11-10；最后修改日期：2024-05-08。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.7 Å。引用文献：《结合抗真菌药物泊沙康唑（Posaconazole）与氟康唑（fluconazole）的克氏锥虫（Trypanosoma cruzi）与布鲁氏锥虫Cyp51的结构表征》，刊载于《PLOS被忽视热带病》（Plos Negl Trop Dis），2010年，第4卷。