Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

Supplementary Data files to accompany manuscript by Harding et al "Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1" Supplementary Data 1 - Multiple sequence alignment for HTT used for Consurf analysis Supplementary Data 2 - Multiple sequence alignment for HAP40 used for Consurf analysis Supplementary Data 3 - Apo HTT cryo-EM map Supplementary Data 4 - HTT-HAP40 Q23 regularised SAXS profile Supplementary Data 5 - HTT-HAP40 Q54 regularised SAXS profile Supplementary Data 6 - HTT-HAP40 Δexon 1 regularised SAXS profile Supplementary Data 7 - XL-MS data Supplementary Data 8 - HTT-HAP40 ensemble weightings Supplementary Data 9 - HTT-HAP40 Q23 ensemble models Supplementary Data 10 - HTT-HAP40 Q54 ensemble models Supplementary Data 11 - HTT-HAP40 Δexon 1 ensemble models哈丁（Harding）等人发表的题为《亨廷顿蛋白结构由HAP40调控，并展现出与外显子1相关的多聚谷氨酰胺扩增特异性相互作用》的论文配套补充数据文件： 补充数据1：用于Consurf (Consurf)分析的亨廷顿蛋白 (HTT) 多序列比对文件 补充数据2：用于Consurf (Consurf)分析的HAP40多序列比对文件 补充数据3：空载亨廷顿蛋白 (HTT) 冷冻电镜 (cryo-EM) 图谱 补充数据4：HTT-HAP40 Q23的正则化小角X射线散射 (SAXS) 曲线 补充数据5：HTT-HAP40 Q54的正则化小角X射线散射 (SAXS) 曲线 补充数据6：HTT-HAP40 Δ外显子1的正则化小角X射线散射 (SAXS) 曲线 补充数据7：交联质谱 (XL-MS) 数据 补充数据8：HTT-HAP40集合体权重数据 补充数据9：HTT-HAP40 Q23集合体模型 补充数据10：HTT-HAP40 Q54集合体模型 补充数据11：HTT-HAP40 Δ外显子1集合体模型