Imbalance of “a-series”-“b-series” composition in GD1(d20:1–20:0) in the brains harboring Aß deposition.

Composition of GD1-gangliosides in relation to a- and b-series of gangliosides. The proportion of each ganglioside in detected gangliosides is expressed as mean with ± SEM in parentheses. P1, C1, P2, and C2 indicate lipid samples extracted from SPMs of the amyloid-free precuneus, the calcarine cortex of the brain with the amyloid-free precuneus, the amyloid-bearing precuneus, and the calcarine cortex of the brain with the amyloid-bearing precuneus, respectively.Imbalance of “a-series”-“b-series” composition in GD1(d20:1–20:0) in the brains harboring Aß deposition.