CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis

NIAID Data Ecosystem2026-05-01 收录

肝细胞癌肿瘤干细胞

Yap信号通路

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CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis

创建时间：

2023-04-21

Shear stress activates YAP to promote motility in human prostate cancer cells. Homo sapiens

癌细胞迁移

Yap信号通路

Biophysical features of the microenvironment such as stiffness of extracellular matrix (ECM), nanotopography, and biomechanical force are critical regulators of cellular potential and behavior, yet th

NIAID Data Ecosystem60

Differential Gene expression in the mouse mammary tumors of PyMT-Malat1 wild-type (WT), PyMT-Malat1 knockout (KO) and PyMT-Malat1 knockout with Malat1 transgene expression (TG)

差异基因表达分析

Yap信号通路

Previously, lncRNA Malat1 knockout mice were generated by insertional inactivation. By crossing this line to MMTV-PyMT mammary tumor mouse model, we produced PyMT;Malat1 wild-type (WT) and PyMT;Malat1

NIAID Data Ecosystem40

Effect of YAP overexpression on HuCCT1 cholangiocarcinoma cell line transcriptome (shRNA targeting YAP). Homo sapiens

肿瘤转录组学

Yap信号通路

The YAP pathway in regulating organ size by integrating external signals to control the expression of genes involved in cell proliferation. YAP is known to be involved in tumorigenesis in several tiss

NIAID Data Ecosystem30

Hippo-YAP/TAZ signaling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass. Hippo-YAP/TAZ signaling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

脂肪可塑性

Yap信号通路

Adipose tissue contributes to systemic energy homeostasis by serving as an energy reservoir and endocrine organ. Coordinated regulation of these functions is essential for metabolic health, but the me

NIAID Data Ecosystem60

Transcriptional effects of YAP/TAZ knockdown in fibroblasts. Transcriptional effects of YAP/TAZ knockdown in fibroblasts

成纤维细胞衰老

Yap信号通路

Gene expression profiles of the cells composing the dorsal skin of young control and YAP/TAZ knockout mice with the skin of a old mouse. Overall design: Single cell profiles were derived from the dors

NIAID Data Ecosystem40

CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis

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