Transcriptional profilers of ABCs, memory B cells, naive B cells, and FLS cocultured with and without ABCs

Age-Associated B Cells (ABCs) are novel B cell subsets, expansion of human ABCs has been observed in many autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren's syndrome, and multiple sclerosis. However, the role of ABCs remains poorly understood in RA. This study first compares the transcriptome differences of ABCs with memory B and naive B cells, then ABC cocultured FLS and FLS alone, which provides insights into the mechanism of pro-inflammatory and chemotactic effects of ABCs.