Bulk RNA sequencing of Bone Marrow Endothelial Progenitor Cells from Patients with Myelodysplastic Syndromes

Myelodysplastic syndromes(MDS) are a group of heterogeneous disease. Emerging evidence has shown the bone marrow(BM) endothelial progenitor cells(EPCs) are also heterogeneity. To uncover the underlying mechanism of heterogeneous BM EPCs in different types of MDS patients. RNA sequencing(RNA-seq) analyses were performed to analyse BM EPCs at day 7 in culture from lower-risk MDS(N=3), higher-risk MDS(N=3), acute myloid leukemia(AML) patients(N=3) and healthy donors(HDs)(N=3). We analysed the hematopoiesis- and immune-related genes and pathways. mRNA profiles of BM EPCs at day 7 in culture from lower-risk MDS(N=3), higher-risk MDS(N=3), AML patients and HDs