A cholesterol-lowering diet score correlates with serum LDL-cholesterol: Results from the DEDiCa trial

A cholesterol-lowering diet score, previously developped for epidemiological studies on seven dietary indicators, was tested to reflect serum cholesterol levels using data from DEDiCa clinical trial. Breast cancer patients with the highest adherence to the cholesterol-lowering diet reported lower LDL-cholesterol than those scarcely adherent (107 and 122 mg/dL, respectively; <em>p</em>=0.04). The difference was significant after adjustment for age, obesity, and physical activity. This provides support for the use of this score to identfy dietary patterns that reduce serum cholesterol levels.本研究采用DEDiCa临床试验的数据，对此前为开展7项饮食指标相关流行病学研究所开发的降胆固醇饮食评分展开测试，以验证其可用于反映血清胆固醇水平。依从该降胆固醇饮食程度最高的乳腺癌患者，其低密度脂蛋白胆固醇（LDL-cholesterol）水平显著低于依从性极低的患者（分别为107 mg/dL与122 mg/dL；*p*=0.04）。在校正年龄、肥胖状况与体力活动水平后，该差异仍具有统计学意义。上述结果支持采用该评分识别可降低血清胆固醇水平的饮食模式。