the data for the article of "Evaluation of Inflammatory Parameters in Patients with Acute Retinal Necrosis"

Abstract:Introduction: Acute retinal necrosis (ARN) is a vision-threatening viral uveitis. This study aimed to evaluate theclinical characteristics of patients with ARN and compare the blood gamma-glutamyl transferase (GGT)-to-lymphocytecount ratio (GLR) and neutrophil-to-lymphocyte ratio (NLR) between patients with ARN and healthy controls.Methods: This is a retrospective case-control observational study. Twenty patients with ARN who were diagnosed inBeijing Chaoyang Hospital between July 2017 and October 2021 were enrolled in this study. Sex- and age-matchedhealthy individuals from the same period were classified as the control group. The disparities in albumin, prealbumin,GGT, NC, LC, NLR, mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), neutrophil-to-albumin ratio(NAR), and GLR between both groups were analyzed. The clinical features of patients with ARN were evaluated.Results: The median age of patients with ARN was 49.05 years. 15 (75%) were infected with varicella zoster virus(VZV), 1 (5%) was infected with herpes simplex virus (HSV), and 4 (20%) had no infection testing. Retinal detachmentoccurred in 6 patients (30%). Prealbumin (P=0.019) and NC (P=0.025) were significantly higher in male patients thanin female patients, whereas other baseline data showed no significant differences between male and female patients(P>0.05). There were significant differences in the NC (P=0.001), NLR (P=0.017), and GLR (P<0.001).Discussion: This report indicated that these blood-derived markers may serve as auxiliary indicators of systemicinflammation in ARN.Conclusion: The ARN group had significantly higher levels of NC (p=0.001), NLR (p=0.017), and GLR (p < 0.001)than those in the control group.