Electrophysiology dataset describing function of hERG potassium channels expressed in HEK cells

High-throughput patch clamp electrophysiology dataset acquired on Nanion syncropatch 384PE platform describing voltage dependent gating of hERG potassium channels expressed in HEK cells.
Specific voltage protocols:
1) Steady state activation
2) Steady state deactivation
3) Onset of inactivation
This example dataset accompanies the methods paper: Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology by Chai-Ann Ng, Jessica Farr, Paul Young, Monique J. Windley, Matthew D. Perry, Adam P Hill, View ORCID ProfileJamie I Vandenberg.
Preprint available at : https://doi.org/10.1101/2021.02.02.427891

本数据集为在Nanion syncropatch 384PE平台上采集的高通量膜片钳电生理数据集，描述了在HEK细胞中表达的hERG钾通道（human ether-à-go-go-related gene potassium channels）的电压依赖性门控特性。
所采用的特定电压刺激方案包括：
1） 稳态激活
2） 稳态去激活
3） 失活起始

本示例数据集随下述方法学论文一同发布：《利用Flp-In HEK293细胞与高通量自动化膜片钳电生理技术进行KCNH2杂合变异体表型分型》，作者为Chai-Ann Ng、Jessica Farr、Paul Young、Monique J. Windley、Matthew D. Perry、Adam P Hill、Jamie I Vandenberg（可查看其ORCID个人档案）。
该论文预印本可通过以下链接获取：https://doi.org/10.1101/2021.02.02.427891