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Pregnancy-associated alterations in DNA methylation patterns of mammary epithelial stem cells [mRRBS]

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NIAID Data Ecosystem2026-03-10 收录
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Mammary gland development and luminal differentiation occur largely postnatally during puberty and pregnancy. We found that pregnancy had the most significant effects on stem cells, inducing a distinct epigenetic state that remained stable through life. Overall design: Mammary glands were collected from mice at non-pregnant and pregnant stages for DNA extraction and DNA methylation analysis via mRRBS (multiplexed reduced representation bisulfite sequencing).

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2018-03-29
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