pme-2020-0172 - Supplementary Table S2

Supplementary Table
S2. Fst p-values (above diagonal) and Fst genetic distances (below diagonal)
among 14 populations for the SLCO1B1 gene variant rs4149056.

Aims. To evaluate the genetic distribution of
the rs4149056 and rs2306283 variants into the SLCO1B1 gene in Mexican Mestizo
(admixed) and Native American groups. Patients & Methods. We recruited 360
volunteers who were qPCR-genotyped with TaqMan probes. Results. Allele and
genotype frequencies are reported. Among the expected rs4149056–rs2306283
haplotypes, T–A (42.35 to 58.47%) was the most prevalent which relates to the
normal activity of the OATP1B1 transporter. This was followed by the T–G
haplotype associated with further statin transport and cholesterol reduction
(32.49 to 43.76%). Conclusions. Based on these SLCO1B1 gene variants, we
confirmed that a minimum fraction of the Mexican study populations would be at
risk from decreasing simvastatin transport, and the development of
statin-induced myopathy.